The Laboratory of Fundamental and Applied Bioenergetics (LBFA) is situated at the UGA campus in St. Martin d’Hères/Gières. On about 3000 m2 laboratory and office space, including its recent state-of-the-art research building “Xavier Leverve”, LBFA offers an ideal research environment for molecular and metabolic research in the field of bioenergetics. This includes facilities for proteomics/protein biochemistry, cell culture, metabolic analysis, imaging/cytometry and animal physiology.
describes the way energy is transformed within an organism from nutritional uptake to generation of ATP and cellular work. It is central to all fundamental biological processes and many human pathologies, including chronic diseases like metabolic syndrome, type II diabetes or cardiovascular diseases. Our ambition is to develop both fundamental and (pre)clinical projects to unveil bioenergetics in different organs and pathologies. Its final goal is to understand molecular mechanisms, develop preventive strategies, and propose diagnostic and therapeutic approaches.
A first mitochondrial metastasis suppressor
Bad outcome in cancer mainly depends on the tumor’s capacity to migrate and invade, thus spreading in the body and forming metastasis (secondary tumors). Few cellular proteins can slow or prevent this process, the so-called metastasis suppressors.
is a promising therapeutic approach for sarcopenia and known to stimulate the highly energy-dependent protein synthesis in muscle. We show that citrulline stimulates protein synthesis under limiting conditions like amino acid deficiency or energy stress. This increase was not due to enhanced energy state (ATP/ADP ratio) or mitochondrial respiration, but to energetic rewiring that reallocates mitochondrial fuel to the protein synthesis machinery.
HealthProbe - screening cellular health
Energy availability is a crucial indicator of cellular health. Here we develop our genetically-encoded, fluorescent energy sensor AMPfret (Pelosse et al., Nature Communications 2019, 10:1038) into applications for cosmetic and pharmaceutical industry.
LBFA has a job opening for a tenure-track Junior Professor Chair
We are looking for candidates with a proven scientific track record in metabolic and bioenergetic research.
After a pre-tenure contract (4 years) and an assessment, the candidate obtains full tenure as an Inserm Research Director (DR2).
The opening date for applications will be in early 2024.
For the profile and more details see:
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If you are interested in doing a M2 training, LBFA has regularly avalaible positions.
LBFA can offer PhD or postdoctoral positions. You can contact us for more informations.
You can find here the complete list of our publications.
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