describes the way energy is transformed within an organism from nutritional uptake to generation of ATP and cellular work. It is central to all fundamental biological processes and many human pathologies, including chronic diseases like metabolic syndrome, type II diabetes or cardiovascular diseases. Our ambition is to develop both fundamental and (pre)clinical projects to unveil bioenergetics in different organs and pathologies. Its final goal is to understand molecular mechanisms, develop preventive strategies, and propose diagnostic and therapeutic approaches.

Bad outcome in cancer mainly depends on the tumor’s capacity to migrate and invade, thus spreading in the body and forming metastasis (secondary tumors). Few cellular proteins can slow or prevent this process, the so-called metastasis suppressors.

is a promising therapeutic approach for sarcopenia and known to stimulate the highly energy-dependent protein synthesis in muscle. We show that citrulline stimulates protein synthesis under limiting conditions like amino acid deficiency or energy stress. This increase was not due to enhanced energy state (ATP/ADP ratio) or mitochondrial respiration, but to energetic rewiring that reallocates mitochondrial fuel to the protein synthesis machinery.

Energy availability is a crucial indicator of cellular health. Here we develop our genetically-encoded, fluorescent energy sensor AMPfret (Pelosse et al., Nature Communications 2019, 10:1038) into applications for cosmetic and pharmaceutical industry.

« Eclats de science » édition 2023 :  l’activité physique est à l’honneur.
A quelques mois des JO de Paris, l’UGA met à l’honneur les recherches en sport et activités physiques menées dans ses laboratoires.