Project ThermoCreatine (ANR)

Recent research has uncovered a novel molecular mechanism for heat production in beige and brown adipocytes, potentially revolutionizing our comprehension of adaptive thermogenesis. This mechanism revolves around a creatine futile cycle (CFC), which generates heat via the phosphorylation and dephosphorylation of creatine.

This innovative mechanism has garnered significant attention for its potential to offer an alternative pathway for heat generation in brown and beige adipocytes, triggered by cold exposure or dietary factors. 

Through comprehensive characterization of the enzymatic activities and heat generation capacity of the CFC, both in vivo and in vitro, our research aims to provide critical insights into this novel thermoregulatory mechanism. Understanding how to activate or regulate such adaptive thermogenesis to enhance systemic energy expenditure offers promising new avenues for combating obesity and metabolic disorders.