Homepage Isabelle Hininger-Favier

Isabelle Hininger-Favier, MCU

Assistant Professor , UFR Health

Educational Manager of University Degree in Nutrition for health professionals



 

• Her research focus on nutrition and redox biology. She has published more than 80 articles submitted to review committees. She investigates oxidative stress and redox biology induced by ageing, iron, western-diet on insulin-resistance and on brain and the possible amelioration of these effects with proper nutrients. She has developed oxidative stress methods like the comet assay to assess DNA damage on blood. She analyzed oxidative stress during ageing and under other oxidative stress/inflammatory conditions (high glucose), in conjunction with changes in cellular function and signal transduction on brain. Notably, she has shown that a high iron status increase hyperglycemia and DNA damage during early pregnancy both on experimental model and clinical study. She has shown that phenolic compounds (i.e cinnamon, green tea and blueberries extracts) have beneficial effects on glucose tolerance, including enhanced glucose and redox signaling and prevent oxidative and inflammatory damage on brain. Her research has been done on cells, animals and she conducted and collaborated to several clinical nutrient studies on healthy populations (adult, elderly and pregnant women).
• She collaborates with international team at the Human Nutrition Research Center on Ageing (Boston, USA); Medical University of Colorado (Aurora, USA).
• Member of the American Society of Nutrition (ASN)
• President of SFERETE (French-speaking society for research on trace elements) (2006-2013)

• Determine the mechanisms by which selected nutrients influence redox-signaling.
• Determine the relationships between specific foods, nutrients, and other bioactive dietary components and healthy ageing, such as cognitive function

Ph.D., Physiology and pathology in human nutrition, Paris 7 University

Post-doctoral fellow at Lab oxidative stress (Pr.A. Favier). UJF-Grenoble, Fr



 

Nutrition, Brain, and Ageing



 

Number of citations: 4463

Index-H: 36



Last 4 years released articles :

 

• Teniou S, Bensegueni A, Hybertson B.M., Gao B. , Bose S.K., McCord J. , Chovelon B , Chawki Bensouici C., Boumendjel A. , Hininger-Favier I. Biodriven investigation of the wild edible mushroom Pleurotus eryngii revealing unique properties as functional food. Journal of Functional Foods. 2022. 89. 104965. IF=4,35.
• Kay  L, Potenza L. , Hininger-Favier I., Roth H. , Attia S., Tellier C., Zuppinger C.  , Calcabrini C., Sestili  P.2 , Wallimann  T.4 , Schlattner U., Tokarska-Schlattner. Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin. Nutrients 2022, 14, 583.
• I. Hininger-Favier, N. Thangthaeng, D.F. Bielinski, D.R. Fisher, Poulose S.M.  and B. Shukitt-Hale. Blueberries and insulin protect microglial cells against high glucose-induced inflammation and restore GLUT-1. Journal of Berry Research.2021.11 201–216 201 DOI:10.3233/JBR-200628. IF=2,5
• Tokarska-Schlattner M, Kay L, Perret P, Isola R, Attia S, Lamarche F, Tellier C, Cottet-Rousselle C, Uneisi A, Hininger-Favier I, Foretz M, Dubouchaud H, Ghezzi C, Zuppinger C, Viollet B, Schlattner U. Role of Cardiac AMP-Activated Protein Kinase in a Non-pathological Setting: Evidence From Cardiomyocyte-Specific, Inducible AMP-Activated Protein Kinase α1α2-Knockout Mice. Front Cell Dev Biol. 2021,18;9:731015. doi: 10.3389/fcell.2021.731015. eCollection 2021.PMID: 34733845 . IF=6,68
• Lacombe ML, Lamarche F, De Wever O, Padilla-Benavides T, Carlson A, Khan I, Huna A, Vacher S, Calmel C, Desbourdes C, Cottet-Rousselle C, Hininger-Favier I, Attia S, Nawrocki-Raby B, Raingeaud J, Machon C, Guitton J, Le Gall M, Clary G, Broussard C, Chafey P, Thérond P, Bernard D, Fontaine E, Tokarska-Schlattner M, Steeg P, Bièche I, Schlattner U, Boissan M. The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor. BMC Biol. 2021;19(1):228. doi: 10.1186/s12915-021-01155-5.PMID: 34674701 . IF=7,43
• Pinto MM, Dubouchaud H, Jouve C, Rigaudière JP, Patrac V, Bouvier D, Hininger-Favier I, Walrand S, Demaison L..  A chronic low-dose magnesium L-lactate administration has a beneficial effect on the myocardium and the skeletal muscles. J Physiol Biochem 2021 22. doi: 10.1007/s13105-021-00827-8. Online ahead of print.PMID: 34292519. IF: 4,58
• Batandier C, Poyot T, Marissal-Arvy N, Couturier K, Canini F, Roussel AM, Hininger-Favier I.  Acute emotional stress and high fat/high fructose diet modulate brain oxidative damage through NrF2 and uric acid in rats. Nutr Res. 2020.Jul;79:23-34. doi: 10.1016/j.nutres.2020.05.009. Epub 2020 , 22.PMID: 32610255. IF=3,14
• Agostini M, Hininger-Favier I, Marcourt L, Boucherle B, Gao B, Hybertson BM, Bose SK, McCord JM, Millery A, Rome M, Ferreira Queiroz E, Wolfender JL, Gallet C, Boumendjel A.. Phytochemical and Biological Investigation of Helianthemum nummularium, a High-Altitude Growing Alpine Plant Overrepresented in Ungulates Diets. Planta Med. 2020 Nov;86(16):1185-1190. doi: 10.1055/a-1197-2898. Epub 2020 Jul 9.PMID: 32645735. IF=3,35
• Leger T, Jouve C, Hininger-Favier I, Rigaudiere JP, Capel F, Sapin V, Moreau C, Charrier A, Demaison L. EPA is Cardioprotective in Male Rats Subjected to Sepsis, but ALA Is Not Beneficial.Antioxidants (Basel). 2020; 29;9(5):371.doi:10.3390/antiox9050371.PMID: 32365668. IF=6,64
• Siti F, Dubouchaud H, Hininger I, Quiclet C, Vial G, Galinier A, Casteilla L, Fontaine E, Batandier C, Couturier K. Maternal exercise before and during gestation modifies liver and muscle mitochondria in rat offspring. J Exp Biol. 2019 May 16;222(Pt 10):jeb194969. doi:10.1242/jeb.194969.PMID: 31019067. IF:3,32
• Jacquet A, Arnaud J, Hininger-Favier I, Hazane-Puch F, Couturier K, Lénon M, Lamarche F, Ounnas F, Fontaine E, Moulis JM, Demeilliers C. Impact of chronic and low cadmium exposure of rats: sex specific disruption of glucose metabolism. Chemosphere. 2018 Sep;207:764-773. doi: 10.1016/j.chemosphere.2018.05.099. Epub 2018 May 20.PMID: 29859488. IF:7,086
• Hadj Ahmed S, Kharroubi W, Kaoubaa N, Zarrouk A, Batbout F, Gamra H, Najjar MF, Lizard G, Hininger-Favier I, Hammami M. Correlation of trans fatty acids with the severity of coronary artery disease lesions. Lipids Health Dis. 2018 Mar 15;17(1):52. doi: 10.1186/s12944-018-0699-3.PMID: 29544473.IF =3,57
• Leger T, Hininger-Favier I, Capel F, Geloen A, Rigaudière JP, Jouve C, Pitois E, Pineau G, Vaysse C, Chardigny JM, Michalski MC, Malpuech-Brugère C, Demaison L. Dietary canolol protects the heart against the deleterious effects induced by the association of rapeseed oil, vitamin E and coenzyme Q10 in the context of a high-fat diet. Nutr Metab (Lond). 2018 Feb 13;15:15. doi: 10.1186/s12986-018-0252-4. eCollection 2018.PMID: 29456586. IF:3,93

Hininger-Favier I., J-M Moulis, J-M Ayoubi. Iron and Oxidative stress in gestational diabetes. In Nutrition and diet in maternal diabetes : an evidence-based approach.2018. Edts Rajendram R, Preedy V.R., Patel V.B. Nutrition and Health. Humana Press. Internal Medicine. London UK. Series editors Adrianne Bendich. Connie W. Bales. ISBN 978-3-319-56438-8.