Project NME_CoA (ANR)

Acetyl-CoA (acetyl-coenzyme A) is an evolutionarily ancient and abundant cellular metabolite. Beyond its role in fueling mitochondrial respiration, it primarily participates in two competing metabolic pathways: de novo lipogenesis (DNL) and histone/protein acetylation.

A consortium at UGA Grenoble has made a significant discovery : members of the NME protein family serve a pivotal function in maintaining acetyl-CoA/CoA homeostasis and distribution by binding to and transporting these metabolites. Disruption of cytosolic NME results in increased fatty acid content in the liver, leading to liver steatosis under a high-fat diet.

The NME_CoA project aims to comprehensively characterize the binding of Ac-CoA/CoA by NME proteins, shedding light on critical new regulatory hubs that govern major metabolic pathways and revealing their impact on the physio-pathological epigenetic reprogramming of the liver.