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Jonathan Gaucher (PhD, HP2, Université Grenoble Alpes)


On March 21, 2024

« Time Matters: Circadian Control of Oxygen Metabolism »

Summary :
The circadian integration of cellular metabolism may have conferred an evolutionary advantage to capitalize environmental resources and to optimize energy harvesting and utilization through the light/dark cycle. Circadian disruption has been linked to broad pathological consequences including sleep disorders, cardiovascular and metabolic diseases. Cellular metabolism is highly reliant on oxygen and its dysregulation is evident in numerous pathological conditions such as sleep apnea, chronic obstructive pulmonary disease, stroke and cancers. Several studies have demonstrated interconnections between cellular metabolism, epigenetic mechanisms, hypoxia and circadian rhythms. These interconnections can affect the ability of cells, organs, and organisms to sense and respond to changes in oxygen levels. However, limited knowledge exists regarding these interconnections in pathological conditions such as sleep apnea, a particularly relevant disease since intermittent hypoxia occurs only during a specific circadian time period, namely sleep. Using multi-omics integration we identified molecular tracers of intermittent hypoxia including circadian, metabolic and epigenetic regulators. These distinctive signatures associated with the progression of organ injury offer potential diagnostic and treatment response markers.


On March 21, 2024
Complément date


Complément lieu
Salle de Réunion
Domaine Universitaire
LBFA Bâtiment B Biologie
2280 Rue de la piscine
38400 Saint Martin d'Hères

Submitted on March 19, 2024

Updated on April 24, 2024