Charles Thomas, PhD, MC "Role of mitophagy in myeloid cell activation"

Charles THOMAS, PhD 

Summary :

"Our research group is focused on understanding the role of mitochondrial function in myeloid cells during inflammation, both in septic and sterile contexts. Specifically, we are interested in the process of mitophagy and its impact on myeloid cell activation. Through a translational approach from cells to patients, we demonstrated that STAT1 signaling inhibits mitophagy in monocytes and macrophages during sepsis, leading to mitochondrial ROS-dependent activation of these cells. This activation enhances their bactericidal activity and promotes survival. Currently, we are investigating whether this interaction between STAT1 signaling and mitochondrial function in myeloid cells may also contribute to sterile inflammation, particularly in age-related atherosclerosis".