Karine Couturier, MCU

 

Research Interest

“I am interested in the role of maternal environment on the future health of offspring, according to the Developmental Origins of Health and Disease (DOHaD) Concept. Currently, my work is centered on the effects of exercise during pregnancy and/or lactation by the mothers on the metabolic health of their offspring. Our main results show that such exercise during pregnancy is able to alter the pancreas structure and function in the offspring. When exposed to a high-fat diet, pancreas of offspring from trained mothers present a higher insulin secretory capacity and higher muscle insulin sensitivity and gain less fat mass. We also demonstrated that exercise during lactation is able to modify the nutrient quality of the milk and that these changes could affect the offspring pancreatic function. Maternal training consequences on offspring can be either beneficial or deleterious depending on its age and on its nutritional environment.

This work is complementary to studies in the framework of the DOHaD concept and strengthens the idea that the environment during the first stages of life will have short- to long-term impacts on the health of the individual. I implement methods and procedures to conduct these studies in the laboratory, including glucose and insulin tolerance tests, body composition assessment, exercise training programs in rodents, pancreatic islet isolation."
 
Short Biography

Vice-Director UFR Activités Physiques et Sportives
Principal Investigator, Laboratoire de Bioénergétique Fondamentale et Appliquée
Head of the Animal Welfare Board of the BEeSy Animal Facility Université Grenoble Alpes
MSc Exercise Physiology, University of Montréal, Québec, Canada
PhD in Exercise Physiology, Bi-national doctorate University Lyon, France and University of Montréal, Québec, Canada
Postdoctoral Research Fellow, University of Savoie Mont-Blanc, France
Visiting Professor at CVS, University of Edinburgh
 
Keywords

exercise, gestation, lactation, offspring, pancreas, carbohydrates, lipids, mitochondria
 
References
  • Siti F., Dubouchaud H., Hininger-Favier I., Quiclet C., Vial G., et al (2019). Maternal exercise before and during gestation modifies liver and muscle mitochondria and redox status in rat offspring. J Exp Biol 16;222(Pt 10).Quiclet C., Siti F., Dubouchaud H., Vial G., Berthon P., et al (2016). Short-term and long-term effects of submaximal maternal exercise on offspring glucose homeostasis and pancreatic function. Am J Physiol Endocrinol Metab 311(2):E508-18.
  • Regnault C., Usal M., Veyrenc S., Couturier K., Batandier C., et al (2018). An unexpected metabolic syndrome induced by endocrine disruptors in Xenopus tropicalis: a new lead for understanding amphibian decline. Proc Natl Acad Sci U S A 115(19):E4416-E4425.
  •  Quiclet C., Dubouchaud H., Berthon P., Sanchez H., Vial H., et al (2017). Maternal exercise modifies body composition and energy substrates handling in male offspring fed a high-fat/high-sucrose diet. J Physiol 595(23):7049-7062.
  • Quiclet C., Siti F., Dubouchaud H., Vial G., Berthon P., et al (2016). Short-term and long-term effects of submaximal maternal exercise on offspring glucose homeostasis and pancreatic function. Am J Physiol Endocrinol Metab 311(2):E508-18.